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Comfort Chicken Biscuit Casserole Recipe

Comfort Chicken Biscuit Casserole Recipe


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4.9 from 15 reviews

  • Total Time: 35-40 minutes
  • Yield: 4 1x

Description

Chicken and biscuit casserole brings warm hugs from your kitchen straight to the dinner table. Creamy chicken nestled under flaky golden biscuits makes comfort food that feeds both body and soul.


Ingredients

Scale

Main Ingredients:

  • 2 cups cooked chicken
  • 2 cans (10.5 ounces each) cream of chicken soup
  • 1 can (16.3 ounces) biscuit dough
  • 2 cups mixed vegetables
  • 1 cup shredded cheese

Supporting Ingredients:

  • ½ teaspoon salt
  • ½ teaspoon pepper

Optional Ingredients:

  • ½ teaspoon garlic powder
  • ½ teaspoon onion powder
  • Dried thyme or parsley
  • A few dashes hot sauce

Instructions

  1. Warm your oven to 375F and generously coat a 9×13 inch baking dish with cooking spray.
  2. Mix 2 cups of cooked chicken, 2 cans of cream of chicken soup, 2 cups of mixed vegetables, ½ teaspoon salt, ½ teaspoon pepper, ½ teaspoon garlic powder, and ½ teaspoon onion powder in a large bowl until ingredients are thoroughly combined.
  3. Pour the chicken mixture into the prepared baking dish, spreading the contents evenly across the surface.
  4. Carefully open the refrigerated biscuit dough and slice each biscuit into four equal quarters.
  5. Distribute the biscuit quarters across the top of the chicken mixture, ensuring they are loosely scattered and not tightly packed.
  6. Sprinkle 1 cup of shredded cheddar cheese over the biscuit pieces for extra flavor.
  7. Place the casserole in the preheated 375F oven and bake for 25-30 minutes, watching for biscuits to turn golden brown and filling to become bubbly.
  8. Remove the casserole from the oven and allow it to rest for 5-10 minutes before serving to help the filling set.

Notes

  • Swap out canned soup for homemade white sauce if aiming for a less processed version of the casserole.
  • Frozen vegetable blends work perfectly when fresh vegetables aren’t available, giving consistent flavor and texture.
  • For gluten-free adaptation, use gluten-free biscuit dough and check that cream soup is certified gluten-free.
  • Rotisserie chicken makes this recipe super quick and adds extra flavor to the casserole base.
  • Prep Time: 10 minutes
  • Cook Time: 25-30 minutes
  • Category: Casseroles
  • Method: Baking
  • Cuisine: American

Nutrition

  • Serving Size: 4
  • Calories: 425 kcal
  • Sugar: 4 g
  • Sodium: 780 mg
  • Fat: 20 g
  • Saturated Fat: 9 g
  • Unsaturated Fat: 10 g
  • Trans Fat: 0.5 g
  • Carbohydrates: 30 g
  • Fiber: 3 g
  • Protein: 30 g
  • Cholesterol: 70 mg